"I have driven this van for 10 years. Very reliable I bought and had a wheelchair lift and tie downs put in so I could take my mom in it. Only draw back is gas mileage but gets about 18 on highway which isn't too bad for a big box."
"I bought my2006 E250 with 100,000 miles on it it now has 202,xxx miles on it. This van has been great and towing at least 3 days a week approximately 9600 lbs. It is not a speed demon at this wieght, but it will get us there. The van I do wish had a larger motor, but the 4.6L has been great. The only complaint I have is the cataylic converters I have changed, and a small battle with the ingnition packs. Other than Those this van has been problem free"
"I use this van everyday running a plumbing service business. The only issue I have is with the small 4.2 V-6. It performs well considering the truck is always "heavy" due to what we carry. The fuel economy listed is 13/15 which is way out of line. On good days I'm lucky to see 10mpg and just very slightly better on the highway, maybe 11mpg. Friends of mine with the same van but with the small V-8 are seeing 15/20 MPG. Funny though, this was the last model year where Ford used this small engine in these vans. From 2003 and forward the small V-8 was standard"